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Cervical Cancer - Diagnosis 

Contents:

bulletHow is Cancer of the Cervix Diagnosed?
bulletAbnormal Smears and CIN
bulletStages of Cancer of the Cervix

How is Cancer of the Cervix Diagnosed

Cervical cancer can be detected using Pap smear testing. This involves the doctor taking a sample of cells from the cervix, to be examined by a pathologist. Should abnormal cells be found, then further tests will be done to determine if it is cancer of the cervix. If so, the doctor must then determine the location and spread of the cancer. This investigation will reveal whether cancer is localised or has spread to other parts of the body. This process is called staging, and may involve one or all of the following:

bulleta physical pelvic examination, which may be done under an anaesthetic
bulleta cystoscopy to look inside the bladder with a small telescope
bulleta chest X-Ray
bulletX-Ray CT scan of the pelvis and abdomen
bulletblood tests - a full blood count, biochemistry and liver function tests.

Abnormal Smears and CIN

Just because you return an abnormal Pap Smear does not necessarily mean you have cancer. An abnormal test result may mean that you have either atypia, wart virus (also known as Human Papilloma Virus or HPV) changes or CIN.

Atypia usually means that slight inexplicable changes have occurred in the cells of the cervix. If your doctor suspects that Wart Virus is the cause of these changes, you will need to have another Smear in six months, and then another six months later, in order to monitor these changes.

Wart Virus is a virus similar to that which causes warts on other parts of the body. It is commonly cited as a cause of cancer of the cervix. If this virus is detected, you will need to have six-monthly Pap Smears for a year, and you may require a colposcopy.

If the colposcopy shows the virus is present without any other abnormal cells, you should have Pap Smears every six months until you return two consecutive normal smears.

CIN stands for Cervical Intra-epithelial Neoplasia. CIN has the potential to become invasive cervical cancer. CIN is graded into three stages of severity, from CIN 1 (mild dysplasia) through CIN 2 (moderate dysplasia) to CIN 3 (severe dysplasia/carcinoma in situ).

If left untreated, CIN may either return to normal, persist or eventually progress to invasive cervical cancer. Several studies have shown that approximately 33-50% of cases of CIN 1 and 2 return to normal without treatment. Even cases of CIN 3 have been seen to return to normal however, the more severe an abnormality is, the less likely it is to regress.

Progression times from CIN 3 to invasive cancer range from one to 30 years.

Stages of Cancer of the Cervix 

Cancer of the cervix develops in the following stages:

Stage 0 

This stage is also known as carcinoma in situ, or CIN III. This is not true cancer, but a pre-cancerous stage where the abnormal cells are still limited to the superficial skin and have not invaded the deeper tissues of the cervix.

Stage I 

Cancer is limited to the cervix itself.

bulletStage I A 

A very small amount of cancer is present and is only visible with a microscope.

bulletStage I B 

A larger amount of cancer is present and can be seen with the naked eye.

Stage II 

Cancer has spread to areas immediately next to the cervix (parametrium).

bulletStage II A 

Cancer has spread beyond the cervix to somewhere in the upper two-thirds of the vagina.

bulletStage II B 

Cancer has spread to the tissues beside the cervix, but not as far as the side of the pelvis.

Stage III 

Cancer has spread further than stage II, but is still limited within the pelvis.

bulletStage III A 

Cancer has spread to the lower one-third of the vagina

bulletStage III B

Cancer has spread to the side of the pelvis.

bulletStage IV 

Cancer has spread to other parts of the body.

bulletStage IV A 

Cancer has spread to the bladder or rectum.

bulletStage IV B 

Cancer has spread to areas outside the pelvis.

Recurrent 

Recurrent cancer means the cancer has come back (recurred) after it has been treated. It may come back in the cervix, the pelvis, or elsewhere.

 

Prof Alex Crandon

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© 2003 Gynaecological Cancer Society .
Contact Mr John Gower Chief Executive,
Gynaecological Cancer Society, Room 2 Floor H,
Clinical Sciences Building. Royal Brisbane & Womens Hospital, Herston, Queensland, 4029
Phone: +61 7 3365 5216 Fax: +61 7 3635 5216
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